Your Daily Brief

March 30th, 2023

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In Today’s Brief

  • Pope Francis: Contracts lung infection
  • Santa Fe: Shakeup in Rust prosecution
  • MLB: Opening day kicks off today
  • JetBlue: Cutting NYC-area flights

...and more

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Top Tips


Narcan over the counter

The Food and Drug Administration yesterday approved the overdose-reversing drug Narcan to be sold without a prescription.

Narcan–which is the brand name for the drug naxolone–is a nasal spray that can prevent overdoses by blocking the effects of opioids on the brain and restoring breathing. With the agency’s approval, the FDA said that Narcan could become the first opioid treatment drug to be sold over the counter (the FDA first approved Narcan nasal spray in 2015 as a prescription drug). Emergent BioSolutions, the drug’s manufacturer, said it will make Narcan available on shelves in the U.S. and at online retailers by late summer.

The approval from the FDA comes as the U.S. grapples with rising levels of opioid-related deaths. According to data from the National Institute on Drug Abuse, the U.S. reported more than 106K deaths from overdoses in 2021, primarily driven by synthetic opioids such as illicit fentanyl.

AI open letter

Notable figures in artificial intelligence penned an open letter calling for companies in the sector to suspend training of AI systems at certain levels due to theoretical risks to humanity.

Per the letter, which was published on the Future of Life Institute’s website, “AI systems with human-competitive intelligence can pose profound risks to society and humanity” and AI labs are currently “locked in an out-of-control race to develop and deploy ever more powerful digital minds that no one–not even their creators–can understand, predict, or reliably control.” The signatories added that they therefore “call on all AI labs to immediately pause for at least 6 months the training of AI systems more powerful than GPT-4.”

GPT-4 is the technology that powers the AI chatbot ChatGPT developed by OpenAI. As of last night, the letter had been signed by over 1.2K individuals, some of whom have ties to the AI space, including Elon Musk and Apple co-founder Steve Wozniak.

Wooly mammoth meatballs

A food startup unveiled a meatball made from flesh cultivated using the DNA of a wooly mammoth, despite the animal going extinct 4K years ago.

Australian cultured meat company Vow unveiled the meatball at a science museum in the Netherlands. According to Vow, it was developed by joining sheep stem cells with the DNA sequence for mammoth myoglobin–a gene responsible for the meatball’s smell, color, and taste–and filling in gaps with African elephant DNA. Tim Noakesmith, one of Vow's co-founders, said they “chose the wooly mammoth because it’s a symbol of diversity loss and a symbol of climate change.” Since scientists weren’t sure how a person’s immune system would react, nobody has eaten the meatball yet.

Vow is reportedly investigating the potential lab-grown use of other species such as alpacas, kangaroos, and various fish species. The company expects Japanese quail to be its first lab-grown meat served to customers in Singapore later this year.

In partnership with The Brothers Apothecary

CBD superfood gummy, powered by bees


Hemp edibles have a dark secret: they're nearly all made with high-fructose corn syrup, artificial colors, and synthetic flavors. And no, adding 10mg of CBD to that isn't going to make it "healthy." That's why the Brothers decided to change the way things work in the hemp world. Meet the all-new Honey Drop!

Honey Drops are made with simple ingredients, including certified organic honey sourced from small, remote sustainable farms + fruit pectin. Using ultra-low temperatures, the honey is processed to remove moisture and retain all the beneficial plant metabolites, pollen, and goodness of natural honey. Next, they're super-powered with immune loving superfoods. Currently, they offer two delicious flavors, Orange Turmeric and Lemon Ginger, both made with organic ingredients.

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Quick Tips


Around the Globe

  • Pope Francis was hospitalized with a respiratory infection yesterday after a scheduled check-up and will remain in the hospital for “a couple of days of treatment,” per a statement from the Vatican (More)
  • Adidas withdrew its request to the U.S. Trademark Office to reject a Black Lives Matter application for a trademark featuring three parallel stripes that the company originally said would create confusion with its own brand (More)
  • Russia will no longer give the U.S. advance notice about its missile tests as previously outlined in the New START nuclear treaty the Kremlin has suspended, according to a senior Moscow diplomat (More)

On the Homefront

  • Santa Fe District Attorney Mary Carmack-Altwies stepped down from the prosecution of Alec Baldwin for the fatal shooting of Rust cinematographer Halyna Hutchins and named two lawyers to take over the case (More)
  • Clark County medical examiner identifies skeletal remains found in Lake Mead last year as Donald Smith of North Las Vegas, who was 39 at the time of his reported drowning in April 1974 (More)
  • Senator John Fetterman will reportedly return to the Senate during the week of April 17th; last month, Fetterman checked himself into Walter Reed National Military Medical Center to seek treatment for clinical depression (More)

Glitz & Games

  • ‘Black Panther’ director Ryan Coogler is developing an ‘X-Files’ reboot, according to original series creator Chris Carter (More)
  • Major League Baseball Opening Day for the 2023 season is today; all 30 MLB teams will play their first games today for the first time since 1968 (More)
  • CBS renews ‘Blue Bloods’ for a 14th season after the cast and producers agreed to take a 25% pay cut, according to sources familiar with the matter (More)

Business & Markets

  • Major indexes in the stock market ended yesterday’s session higher, with the Nasdaq leading gains (Dow +1.00%, Nasdaq +1.79%, S&P 500 +1.42%)
  • JetBlue is preparing to cut flights in and out of the New York City area this spring and summer due to a shortage of air traffic controllers (More)
  • Macy’s CEO Jeff Gennette will retire in February 2024 after a four-decade career at the department store chain, per a company announcement; Gennette will be succeeded by Tony Spring, CEO of Macy’s subsidiary Bloomingdale’s (More)

Tips & Tricks

  • Feel Good Pt 1: Learn about All Terrain Georgia, an initiative that offers all-terrain wheelchairs to individuals with mobility issues or disabilities so they can explore Georgia’s parks
  • Feel Good Pt 2: India has welcomed the birth of four cheetah cubs more than 70 years after the animals were declared officially extinct there, with the country’s environment minister calling it a “momentous event”
  • Bump This: Jimin of BTS fame has broken out from the South Korean group with the sultry solo single “Like Crazy” - listen on Apple Music, Spotify, and YouTube
  • Sneak Peek: Take a trip to a fictional American desert town circa 1955 in the official trailer for Asteroid City, the upcoming Wes Anderson film featuring Tom Hanks, Scarlet Johansson, Tilda Swinton, and many others
  • Go Deep: Read about what it may end up costing California to pay reparations to Black residents, as the city of San Francisco recently proposed…and the effects that it would potentially have on the state’s budget
  • Hot Goss: As part of the company’s cost-cutting campaign which began this week, Disney has laid off the chairman of Marvel Entertainment, Isaac “Ike” Perlmutter
  • Life Hack: Breakfast is often dubbed the most important meal of the day, and offers a slew of health benefits when it comes to metabolism, energy levels, and muscle building - here are four reasons not to skip breakfast as well as a list of some foods you should avoid eating in the morning

Tip-Offs


America’s most and least-desirable neighborhoods.

…and from best to worst, ranking all 30 MLB stadiums.

Mathematicians discover a new shape with 13 sides.

The world premiere of the Kia EV9 streamed live.

Why Leonardo da Vinci made his paintings with eggs.

A list of the countries that trust AI the most.

…and a peek inside the labs that evaluate AI safety.

Watch a survivalist build a log cabin with his bare hands.

Looking Back…

On March 30th: The perihelion passage of Halley’s Comet is first recorded (240 BC); the United States purchases Alaska from Russia (1867); Columbia Records releases jazz artist Miles Davis’ double album Bitches Brew (1970); Dutch painter Vincent van Gogh is born (1853).

In partnership with The Brothers Apothecary

Quit eating "supplements" made with corn syrup


A lot of wellness products are packaged up with sugar and sub-par ingredients. "Wrapping up a vitamin in 3000mg of sugar just doesn't make sense," according to brothers Shane and Jesse. That's why they started The Brothers Apothecary, and that's what inspired the all-new Honey Drop.

The Honey Drop is unlike any other CBD gummy out there. It's made with organic honey and fruit pectin, then superpowered with medicinal foods, including turmeric, ginger, and delicious citruses. The gummies also include over 25mg of hemp-derived cannabinoids, including CBD, CBG, and CBN,

So go ahead! Kick the corn-syrup and enjoy healthy, delicious honey-based CBD gummies packed with superfoods. Use code TIP25 for 25% off + a free cup of tea.

Please support our sponsors!

Question of the Day


Would you eat a wooly mammoth meatball?

Yes - I have adventurous taste

No - that’s way too weird for me

Yesterday's Results


Did you listen to the ‘Serial’ podcast when it came out?

No (81%)

Yes (19%)

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